Eastern Conference
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Inter Miami | 34 | 22 | 8 | 4 | 79 - 49 | 30 | 74 | WWWLL |
| 2 |
 Columbus Crew | 34 | 19 | 9 | 6 | 72 - 40 | 32 | 66 | WWWLD |
| 3 |
 Cincinnati | 34 | 18 | 5 | 11 | 58 - 48 | 10 | 59 | LWWLD |
| 4 |
 Orlando City | 34 | 15 | 7 | 12 | 59 - 50 | 9 | 52 | WLWDD |
| 5 |
 Charlotte | 34 | 14 | 9 | 11 | 46 - 37 | 9 | 51 | WWLDD |
| 6 |
 New York City | 34 | 14 | 8 | 12 | 54 - 49 | 5 | 50 | WLLWD |
| 7 |
 New York RB | 34 | 11 | 14 | 9 | 55 - 50 | 5 | 47 | WLLWD |
| 8 |
 Montréal | 34 | 11 | 10 | 13 | 48 - 64 | -16 | 43 | WWLWD |
| 9 |
 Atlanta United | 34 | 10 | 10 | 14 | 46 - 49 | -3 | 40 | WDLWW |
| 10 |
 DC United | 34 | 10 | 10 | 14 | 52 - 70 | -18 | 40 | LDWWL |
| 11 |
 Philadelphia Union | 34 | 9 | 10 | 15 | 62 - 55 | 7 | 37 | WDLLL |
| 12 |
 Toronto | 34 | 11 | 4 | 19 | 40 - 61 | -21 | 37 | LLDLL |
| 13 |
 Nashville | 34 | 9 | 9 | 16 | 38 - 54 | -16 | 36 | DLLLW |
| 14 |
 New England Revolution | 34 | 9 | 4 | 21 | 37 - 74 | -37 | 31 | WLLLL |
| 15 |
 Chicago Fire | 34 | 7 | 9 | 18 | 40 - 62 | -22 | 30 | LLDLL |
Western Conference
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Los Angeles | 34 | 19 | 7 | 8 | 63 - 43 | 20 | 64 | WWWLW |
| 2 |
 LA Galaxy | 34 | 19 | 7 | 8 | 69 - 50 | 19 | 64 | WWLWW |
| 3 |
 Real Salt Lake | 34 | 16 | 11 | 7 | 65 - 48 | 17 | 59 | DWWDD |
| 4 |
 Seattle Sounders | 34 | 16 | 9 | 9 | 51 - 35 | 16 | 57 | WWDDD |
| 5 |
 Houston Dynamo | 34 | 15 | 9 | 10 | 47 - 39 | 8 | 54 | WLWDD |
| 6 |
 Minnesota United | 34 | 15 | 7 | 12 | 58 - 49 | 9 | 52 | DWWDD |
| 7 |
 Colorado Rapids | 34 | 15 | 5 | 14 | 61 - 60 | 1 | 50 | LLLLL |
| 8 |
 Portland Timbers | 34 | 12 | 11 | 11 | 65 - 56 | 9 | 47 | DLDDL |
| 9 |
 Vancouver Whitecaps | 34 | 13 | 8 | 13 | 52 - 49 | 3 | 47 | LWLWL |
| 10 |
 Austin | 34 | 11 | 9 | 14 | 39 - 48 | -9 | 42 | LDWLW |
| 11 |
 Dallas | 34 | 11 | 8 | 15 | 54 - 56 | -2 | 41 | WLLDW |
| 12 |
 St. Louis City | 34 | 8 | 13 | 13 | 50 - 63 | -13 | 37 | WWLWL |
| 13 |
 Sporting Kansas City | 34 | 8 | 7 | 19 | 51 - 66 | -15 | 31 | WLLLL |
| 14 |
 San Jose Earthquakes | 34 | 6 | 3 | 25 | 41 - 78 | -37 | 21 | LLWLL |
Qualification to Conference Semifinals
Qualification for Round One
Qualification for the Wild card round