Eastern Conference
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Philadelphia Union | 20 | 12 | 4 | 4 | 40 - 18 | 22 | 40 | WWLWL |
| 2 |
 Toronto | 20 | 12 | 3 | 5 | 27 - 21 | 6 | 39 | LLWLL |
| 3 |
 New York City | 20 | 11 | 3 | 6 | 35 - 21 | 14 | 36 | WWWWD |
| 4 |
 Orlando City | 20 | 9 | 7 | 4 | 34 - 22 | 12 | 34 | WWLDL |
| 5 |
 Columbus Crew | 20 | 9 | 5 | 6 | 29 - 21 | 8 | 32 | WWWWW |
| 6 |
 Nashville | 23 | 8 | 8 | 7 | 24 - 22 | 2 | 32 | DLWWL |
| 7 |
 New York RB | 20 | 8 | 5 | 7 | 28 - 27 | 1 | 29 | DWLWL |
| 8 |
 New England Revolution | 20 | 7 | 6 | 7 | 24 - 24 | 0 | 27 | WLWWL |
| 9 |
 Inter Miami | 20 | 7 | 3 | 10 | 23 - 30 | -7 | 24 | LWLLW |
| 10 |
 Montréal | 20 | 7 | 2 | 11 | 29 - 38 | -9 | 23 | WLLLW |
| 11 |
 Atlanta United | 20 | 6 | 4 | 10 | 23 - 27 | -4 | 22 | LLLWL |
| 12 |
 Chicago Fire | 20 | 4 | 8 | 8 | 31 - 34 | -3 | 20 | DLDDL |
| 13 |
 DC United | 20 | 5 | 4 | 11 | 22 - 37 | -15 | 19 | WWWLL |
| 14 |
 Cincinnati | 20 | 2 | 4 | 14 | 9 - 32 | -23 | 10 | LLLLL |
Western Conference
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Seattle Sounders | 20 | 10 | 6 | 4 | 40 - 21 | 19 | 36 | WWWWL |
| 2 |
 Dallas | 23 | 9 | 8 | 6 | 28 - 24 | 4 | 35 | WWLDL |
| 3 |
 Sporting Kansas City | 19 | 10 | 4 | 5 | 32 - 21 | 11 | 34 | WWWDL |
| 4 |
 Portland Timbers | 20 | 9 | 5 | 6 | 40 - 31 | 9 | 32 | WWLDD |
| 5 |
 Colorado Rapids | 20 | 8 | 8 | 4 | 28 - 21 | 7 | 32 | LWWWL |
| 6 |
 Minnesota United | 19 | 8 | 6 | 5 | 32 - 23 | 9 | 30 | DWWWL |
| 7 |
 Los Angeles | 20 | 8 | 4 | 8 | 36 - 32 | 4 | 28 | WWLDL |
| 8 |
 Vancouver Whitecaps | 20 | 8 | 0 | 12 | 22 - 37 | -15 | 24 | LWLLW |
| 9 |
 San Jose Earthquakes | 20 | 6 | 5 | 9 | 29 - 48 | -19 | 23 | LWWLD |
| 10 |
 LA Galaxy | 20 | 6 | 4 | 10 | 23 - 37 | -14 | 22 | LLWDL |
| 11 |
 Houston Dynamo | 20 | 4 | 7 | 9 | 25 - 34 | -9 | 19 | DDLLL |
| 12 |
 Real Salt Lake | 20 | 4 | 7 | 9 | 23 - 33 | -10 | 19 | DDLLL |
Conference Semifinals & 2021 CONCACAF Champions League
First round & 2021 Leagues Cup
First round
1/8 Final
1/4 Final
1/2 Final
Final